Microbial Diversity and Abundance in Pulmonary Tissue of Patients with Early-Stage Lung Cancer

Background: The composition of lung tissue microorganisms in patients with different types cancer has not yet been determined. Previous studies have shown changes the pulmonary microbial flora cancer. Objectives: This study aimed to investigate differences and correlations among histological Methods: Samples tumor normal from 29 early-stage were collected. samples sequenced using Illumina HiSeq high throughput sequencing technology for 16S rDNA V4 region bacteria. Also, their microbiological characteristics detected, bioinformatics analysis was performed. Results: results abundance showed that bacterial colony two tissues similar, Proteobacteria, Thickwalled Bacteria, Anomalococcus, Bacteroides, Actinobacteria predominating. Analysis diversity found no difference α β between tissue. When analyzing adenocarcinoma, Micrococcales Blastomonas significantly higher than Conclusions: parts is consistent, but dominant varies